Friday, August 6, 2021

Professor of Genomics and Bioinformatics Jean-Michel Claverie

Jean-Michel Claverie, Wiki, Biography, Age

Jean-Michel Claverie is an Emeritus Full Professor of Genomics and Bioinformatics at the School of Medicine of Aix-Marseille University in the Structural and Genomic Information Laboratory, a unit of the French National Research Center (CNRS) that he founded in 1995.

Educations and Institutions

He got his initial training both in biochemistry, computer science and theoretical particle physics at the University of Paris and combined his multidisciplinary education into a Doctorate (Dr. Sc.) on the subject of mathematical modeling of the biological system in 1977.

Early Career

He then successively hold research positions at the Jacques Monod Institute (CNRS) in Paris, then at the Salk Institute in La Jolla, before creating in 1982 one of the first pre-Internet era computational biology laboratories at the Pasteur Institute (Paris) where he remained until 1990. He then returned to the USA, at the National Center for Biotechnology Information (NCBI, NLM-NIH, Bethesda) where he participated to the exciting beginning of the genomic era, as a NIH senior Fogarty scientist, until 1995. Before returning to France, he spent one year as director of bioinformatics at Incyte pharmaceuticals (Palo Alto). Owing to his theoretical background, Jean-Michel Claverie worked on a wide range of topics ranging from the mathematical modeling of ultracentrifugation experiments, microbial and human genetics, cellular immunology, and more recently microbial genomics. Following the discovery and initial characterization of Mimivirus, the first "giant" virus in 2003, he then focused on the search for more giant and/or unconventional viruses in increasingly exotic environments. In the last ten years, his laboratory described four new families encompassing the largest known viruses in terms of particle and genome sizes: the Mega/Mimiviridae, the Pandoraviruses, Pithovirus and Mollivirus. The last two viruses were revived from 30,000 year-old Siberian permafrost, opening the field of "Paleovirology". While continuously searching for more ancient and/or exotic viruses, his laboratory is also involved in deciphering the biology and evolutionary origin of these giant viruses. Along these lines, he and his collaborators recently proposed that many of the viral genes without homologs in the cellular world could have been created de novo from intergenic regions. The laboratory’s approaches include structural, molecular, and cellular biology, high throughput proteomics, genome and transcriptome sequencing, environmental sampling, large-scale comparative genomics and metagenomics, together with the development of relevant bioinformatics methods for sequence analysis and data mining. Jean-Michel Claverie (H index=69, average citation>82) co-authored 261 scientific publications (WOS)(Pubmed: 248) that gathered >21,00 citations from more than 16,000 articles, as well as the best-seller book "Bioinformatics for Dummies". He served as a member of the Board of reviewing editors of the AAAS journal "Science" for 10 years (2002-2012). He was recipient of the CNRS Silver medal in 2003, and became a Knight in the National Order of the Academic Palms in 2016. He was listed among the Highly Cited Researchers in 2018 and 2019 (Clarivate Analytics, Cross-field category). 12 of the articles he co-authored are "highly cited" according to the Web of Science. Jointly with his wife, Dr. Chantal Abergel, he received the Prix JaffĂ© (French Academy of Sciences) in 2019 for their discovery and characterization of several families of giant viruses. In Sept 2019, he became an "Emeritus" professor, victim of the French mandatory retirement law. This will (officially ...) preclude him to lead a research team, apply for funding, or act as a PhD mentor in the university system. He will do his best to get around this regulation and continue his researches. •

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Tuesday, April 14, 2020

TikTok Nutmeg High Challenge: Why It’s Not Safe

There's a new challenge on TikTok, and it involves young people who eat nutmeg in an attempt to get high. However, it is not safe. Don't participate in the TikTok Nutmeg Challenge.

This is why.

According to Healthline, nutmeg is a spice that is also known as Myristica fragrans. You may have tried the fragrant spice on pumpkin pie, eggnog, or Christmas foods and drinks like that. Ingested that way, it is safe. However, is it used as inhalation medication? That can cause big problems. Myristicin is the chemical in nutmeg that is said to make the high. This chemical affects "the central nervous system (CNS) by improving the neurotransmitter norepinephrine," reports Healthline.
Studies have found that eating nutmeg can be dangerous and even fatal.
A study looking at the dangers of nutmeg appeared in the Emergency Medicine Journal. "Nutmeg poisoning is rare but probably not reported and should be considered in recreational substance users with acute psychotic symptoms as well as neuromodulatory signs of the central nervous system that may partially mimic anticholinergic hyperstimulation," he says.


The study documents the case of a teenage girl who had a negative reaction to nutmeg:

An 18-year-old student who was previously well presented complaints of palpitations, drowsiness, nausea, dizziness, thirst, and dry mouth. She was very anxious, restless, and agitated, and described being "in a trance state." He felt specifically "like Jack in the box wanting to get out" but had no hallucinations. He did not complain of urinary or abdominal discomfort and had no history of seizures or migraine. He had an uncomplicated medical and psychiatric history and denied any suicidal ideation. The patient declined to give information on recreational drug use.

It turned out that the girl had eaten nearly 50 grams (g) of nutmeg in a smoothie, according to that study. The girl recovered. This study found that there is not much research on the subject and noted that "nutmeg poisoning has been poorly reported in the literature. Such reports span the period from 1908 to the present day, although some claim that Lobelius reported the first evidence for its effects in 1576 ". The medical literature does report two "fatal overdoses," according to the study, adding that symptoms may include "dry mouth, facial flushing, nausea, instability, epigastric pain, urinary retention, and blurred vision."


Another study on the topic of nutmeg poisoning appeared in The Netherlands Journal of Medicine.

Ingesting nutmeg in large quantities can cause toxic symptoms such as hallucinations, tachycardia, and anticholinergic effects. We describe a case of a 37-year-old woman who experienced unintentional nutmeg self-poisoning. Nutmeg poisoning is likely not properly reported. We suggest thinking specifically about nutmeg ingestion in case of symptoms as mentioned above, ”this study found. "In large quantities, nutmeg has toxic effects including hallucinations, tachycardia, nausea, vomiting, agitation, and hallucinations. Due to these effects, it is occasionally used as a recreational drug. "

It also doesn't take much for nutmeg to be toxic. "Toxic symptoms have been observed with a nutmeg dose of just 5g, equivalent to two teaspoons or two-thirds of a tablespoon of grated nutmeg," the study found.

For all these reasons, just don't do it.

Monday, April 13, 2020

COVID-19 Stimulus Checks: How to Use the IRS Direct Deposit Portal

The Internal Revenue Service (IRS) named its direct deposit portal "Get My Payment". The portal will allow people to establish direct deposits with the IRS, allowing them to get their stimulus payments faster. It will be open and ready for use in mid-April, says the IRS.

Although the portal is not yet open, the IRS has provided information on what it will offer. In addition to offering Americans the ability to establish direct deposit for their stimulus payment, it will allow people the option to track their payment schedule and view their payment status.

The IRS will open this portal no later than Friday, April 17. You can sign up on the IRS Economic Impact Payment page every day to see if the portal is still open.
When the IRS direct deposit portal is open, you will need certain information to set up direct deposit. In particular, you will need your bank information so that the IRS knows where to directly deposit your stimulus payment.

In general, when setting up direct deposit, you generally need to provide the following information: your bank name, your bank account routing, and account numbers, and a number of personal details such as your mailing address, email address, or phone number. You may need to verify your identity in some additional way, such as offering your social security number in addition to your bank information.


Much of the information you provide to the IRS is private, such as your social security number or bank account information. For that reason, Americans should only provide their information through the IRS direct deposit portal, and not through unregistered third-party sites.

If you're not sure where to find your routing and account numbers for your bank account, you can find it in the following three places: on your bank's website, in your bank application, or on a paper check. The routing number on a paper check is nine digits and the account number is longer. The other number is your check number, and you won't need it to set up direct deposit on the IRS portal.

Sunday, April 12, 2020

Are Dollar Stores Open on Easter 2020?

Happy Easter! It is a great day to celebrate the holidays and enjoy some fun at home, even if you are taking refuge at home and social distancing due to the coronavirus. But what if you need to stop by a local Dollar store near you at Easter to pick up some supplies? Is there a Dollar Dollar store open on Easter 2020? Here's a quick look at Family Dollar, Dollar General, and Dollar Tree store hours.

General Dollar at Easter 2020
Dollar General stores are usually open for Easter. However, some stores may have different hours for vacations or due to the coronavirus outbreak, so you'll want to check the online store locator. All stores close at 5 p.m. today except Maine, where stores will be closed all day.

A representative from Dollar General previously told Heavy that vacation hours generally vary by store and customers should check the store locator here for more details.

It is important to remember that Dollar General stores now close an hour earlier every day, not just at Easter, so employees have time to restock shelves and clean stores during the coronavirus outbreak, the chain announced.

Stores will continue to open at their normal hours every day, but the first hour every day will be reserved for high-level carriers and others at risk. These times will allow the most vulnerable customers to buy with less crowds.

The store will also limit purchases of certain items, including paper products, hand sanitizers, and wipes.

Dollar Tree at Easter 2020
Dollar Tree stores are usually open for Easter. Beginning March 18, all Dollar Tree locations began closing at 8 p.m. or before. Due to the coronavirus outbreak, individual storage hours may vary. Find the hours and information of your nearest store here.

Additionally, the first hour that stores are open will be devoted to at-risk customers, including seniors and people with pre-existing conditions, and women who are pregnant.

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Coronavirus: Why Denmark is taking steps to open up again

Denmark is about to make its first move to relax the restrictions imposed to combat the coronavirus.

Starting Wednesday, children ages 11 and under return to schools and daycares, after one month of closure.

It is among the first European countries to attempt to reverse the blockade gradually, just as it was one of the first to impose restrictions.

"It is important that we do not keep Denmark closed any longer than necessary," Prime Minister Mette Frederiksen said when she announced the move last week.

The spread of the coronavirus appears to be under control and the government wants the economy to work again.

But Denmark's movements will be slow and cautious. Frederiksen likened them to walking a tightrope.

"If we open Denmark too quickly again, we run the risk of infections increasing too much and then we will have to close again," he said.

Coronavirus: Are we getting closer to a vaccine or drug?

The coronavirus is spreading worldwide, but there are still no drugs that can kill the virus or vaccines that can protect it.

So how far are we from these life-saving medications?

What kind of progress is being made?
The research is happening at breakneck speed, and there are currently more than 20 vaccines in development. Among those currently underway are:

The first human trial for a vaccine was announced last month by scientists at a laboratory in the American city of Seattle. They have taken the unusual step of skipping any animal research to test the safety or effectiveness of the vaccine.
Australian scientists have begun injecting ferrets with two possible vaccines. It is the first complete preclinical trial to move to the animal testing stage, and researchers say they hope to move to the human testing stage by the end of April.
Tests like these are carried out much faster than would normally be the case, and some are using new approaches to vaccines. It follows that there are no guarantees that everything will turn out well.

But even if these, or any other tests, are successful, manufacturers are not expected to be able to produce a mass-produced vaccine until the second half of 2021.

Remember, there are four coronaviruses that are already circulating in humans. They cause the common cold, and we don't have vaccines for any of them.
Could existing drugs treat coronavirus?
Doctors are testing current antiviral drugs to see if they work against the coronavirus. This speeds up research, as they are known to be safe to give to people.

Trials are being carried out in England and Scotland on a small number of patients with an antiviral called remdesivir. It was originally developed as an Ebola drug, but it also appears effective against a wide variety of viruses.

Similar trials have already been carried out in China and the USA. And results are expected in the coming weeks.

There were high hopes that a couple of HIV drugs (lopinavir and ritonavir) would be effective, but the trial data is disappointing.

They did not improve recovery, reduce deaths, or decrease coronavirus levels in patients with severe Covid-19. However, since the trial was conducted on extremely ill patients (nearly a quarter died), it may have been too late in infection for the drugs to work.

Studies are also being done on an antimalarial drug called chloroquine. Laboratory tests have shown that it can kill the virus, and there is some anecdotal evidence from doctors that seems to help. However, the World Health Organization says there is no definitive evidence of its effectiveness.

Would a vaccine protect people of all ages?
It will almost inevitably be less successful in older people. This is not due to the vaccine itself, but aging immune systems do not respond as well to immunization. We see this every year with the flu shot.

Will there be any side effects?
All medications, even common pain relievers, have side effects. But without clinical trials it is impossible to know what the side effects of an experimental vaccine may be.

This is something regulators will want to watch out for.

Who would receive a vaccine?
If a vaccine is developed, there will be a limited supply, at least in the early stages, so it will be important to prioritize.

Healthcare workers who come into contact with Covid-19 patients would be at the top of the list. The disease is more deadly in older people, so it would be a priority if the vaccine were effective in this age group. However, it may be better to vaccinate those who live with or care for the elderly.
Until a vaccine or treatment is ready, what can I do?
Vaccines prevent infections and good hygiene is the best way to do it right now.

If you are infected with the coronavirus, it will be mild for most people and can be treated at home with bed rest, acetaminophen, and plenty of fluids. Some patients may develop a more serious illness and need hospital treatment.

How is a vaccine created?
Vaccines harmlessly show viruses or bacteria (or even small parts of them) to the immune system. The body's defenses recognize them as invaders and learn to fight them.

So if the body is ever truly exposed, it already knows how to fight infection.
The main method of vaccination for decades has been to use the original virus.

The measles, mumps, and rubella (MMR) vaccine is made using weakened versions of those viruses that cannot cause

Man hosts bingo in field for neighbours in lockdown

A man has been running bingo sessions for his confined neighbors to keep his spirits up.

Mark Henderson has been setting up a bingo machine and speakers in a field near his home in Wallsend, North Tyneside, and inviting his neighbors to join in via Facebook.

Prizes donated by local residents include hand sanitizer, bread, milk, and Easter eggs and winners drop them off at the end of their entries.

Henderson said: "It was my wife Kerry's idea to try to get the street to do things and spread a little positivity. I have to call a little louder because of social distancing, but it has been a lot of fun."